he results of skin irritation tests indicated that there were no irritation in
normal volunteers for cream base, cream containing aril oil and cream containing NLC
and cream containing aril oil-loaded NLC. The wrinkle reducing capacity test indicated
that the cream containing aril oil and cream containing aril oil-loaded NLC presented
significantly reducing of wrinkle. But, the cream containing aril oil-loaded NLC
exhibited significantly the capability to reduce skin wrinkle higher than cream containing
aril oil.