The aim of our study was to examine cognitive performance in relation to pharmacological daily doses of antipsychotic and anticholinergic medications and their combination within specific cognitive domains, namely, declarative memory, information processing, executive function, and attention. As expected for patients suffering from schizophrenia the baseline cognitive performance for all variables was below the one expected for a control population. At a descriptive level patients without medication tended to perform better than those with medication, although still impaired in many different tasks.