aDuloxetine use is supported by a large randomized, controlled trial
14
; data supporting venlafaxine, bupropion, and mirtazapine are
from smaller controlled trials or open-label trials. Owing to their side-effect profiles, tricyclic antidepressants and second-generation antipsy-
chotic agents should be used only for persons who do not have a response to other treatment options. These guidelines are concordant
with recommendations in the American Psychiatric Association Practice Guideline for the Treatment of Patients with Major Depressive Disorder,
third edition.