Treatment of pain in advanced stages of osteoarthritis with the use of transdermal fentanyl leads to clear improvement of mobility of increasing of efficiency of joint function, which is related to improvement of quality of life of the patient.
(2) The observed adverse events occur mainly in the first week of treatment. Nausea, vomiting decreases with simultaneous use of metoclopramide, and the other—somnolence, dizziness, and so on subsided gradually upon treatment.