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This review explores the influence of acculturation on alcohol abuse, gender differences, and health consequences among Hispanic adults in the United States. Past research reveal the alcohol use among the Hispanic adult population in the U.S have indicated high alcohol consumption and more harmful drinking patterns compared to any other ethnic groups. Alcohol is a leading cause of preventable death in the U.S. Alcohol use among Hispanic adults has been shown to be influenced by acculturated factors that involve difficulties of adaptation to a new culture. Previous studies have found mixed findings in on the impact of acculturation on Hispanic adults in the U.S. This review discusses the problem of alcohol use in the U.S and the Hispanic population, which has its health consequences. Acculturation is a topic to be discussed in regard to its influence on the problem of alcohol use among Hispanics adults, and health.