Omega-3 fatty acids are a subset of polyunsaturated fatty acids found in marine sources as eicosapentaenoic acid and
docosahexaenoic acid and in some leafy vegetables, nuts, and oils as a-linolenic acid (ALA). The metabolism of omega-3’s
may explain the cardioprotective effects observed in epidemiologic and experimental studies. Although most data for
cardioprotective effects come from studies of marine sources, vegetable sources of omega-3 fatty acids (a-linolenic acid) may
have similar effects through in vivo conversion to eicosapentaenoic acid and docosahexaenoic acid. This document will
provide an overview of omega-3 fatty acids with a focus on specific sources, metabolism, safety issues, and their potential
indication for cardiovascular prevention. (Am Heart J 2006;151:564- 70.)