Gadung (Dioscorea hispida Dennst) tuber contains dioscorin, an alkaloid with high angiotensin converting enzyme-inhibitory
capacity. In this research, dioscorin was extracted using microwave assisted extraction (MAE). The objectives of this research
were to investigate the influence of ethanol concentration (75 % to 96 % w/w), solvent-material ratio (10 : 1 to 20 : 1) and
microwave power (100 W to 400 W) on the extraction yield, and to develop a mathematic model to represent that process. The
optimum condition for this process was extraction using 85 % aqueous ethanol at solvent-material ratio of 12.5 : 1, and
microwave power of 100 W for 20 min. The mathematic model agreed well with the experimental data with average error of
2.96 %.