The physician should perform a detailed history and physical examination at the initial presentation, noting any findings that point to a diagnosis other than functional dyspepsia (e.g., right upper-quadrant pain with cholelithiasis, exercise association with coronary artery disease, radiation to the back with pancreatitis). Table 3 includes medications and other agents commonly associated with dyspepsia.19 Because the differential diagnosis is broad, the workup can range from empiric therapy to extensive laboratory and imaging studies. Figure 1 is an algorithm for the evaluation and treatment of patients with dyspepsia