Pepino melons can be grown in sun or partial shade but the best production will occur in full sun. Pepinos need well drained soil with plenty of organic matter incorporated. The soil pH should be neutral, ranging from 6.5 to 7.5. Pepino melon doesn't do well with competition and weed suppression is essential. A good mulch will help prevent competing vegetation. Pepino melons can withstand light freezes but it is best to situate the plants in a sheltered area for sustained cold snaps.