supply-shift has been proven to be an efficient strategy for the
production of bioactive metabolites in many other microorganisms
(22e26). However, to the best of our knowledge, little research has
been reported about the effect of shift oxygen supply control
strategy on pigments and citrinin production in the submerged
fermentation of Monascus. Therefore, the article was to investigate
the shift oxygen supply control strategy on Monascus pigments
accumulation and citrinin formation by Monascus ruber HS.4000 in
shake-flask and a 10 L fermentor. Oxygen supply was adjusted in
flask cultivation by variation of medium volumes and rotating rate
in 250 mL flasks. In a 10 L fermentor, aeration and agitation were
adjusted to explore the best oxygen supply conditions for high
pigments yields with low citrinin production.