disease that occurs as a result of immunosuppression. In HIV-1-infected individuals, it can be seen at a wide range of CD4+ T-cell levels, most commonly in bisexual and homosexual patients. Contrary to its name, Kaposi's sarcoma is not an actual sarcoma (i.e., a malignancy of mesenchymal origin). The lesions that characterize Kaposi's sarcoma are not a result of neoplastic transformation of cells but arise from an excessive proliferation of spindle cells mixed with endothelial cells