regimens produced clinically important improvements in exercise-induced angina. Carvedilol appeared to exert a somewhat greater anti-ischemic effect, as indicated by the variable time to 1-mm ST-segment depression. Since the response to the two drugs was equivalent with respect to beta blockade, it is thought that the vasodilatory and antioxidative effects of carvedilol may contribute to its beneficial influence on myocardial ischemia.