Use of selected honey
The potency of honey's antibacterial activity can vary up to a hundred-fold.2 Honey's antibacterial activity is partly due to the high osmolarity created by its sugar content, although this reduces as it is diluted by exudate. Honey with no antibacterial activity beyond its osmolarity ceases to be effective against Staphylococcus aureus when diluted with three or four times its volume of exudate.3 However, honey produced specifically for wound care can still be inhibitory if diluted to 45-60 times its volume. Honey's antimicrobial activity is also due to: Hydrogen peroxide, which is formed in a 'slow-release' manner by the glucose oxidase added by bees during its production Phytochemicals from the nectar of particular plant species. Both activities can vary from sample to sample. In manuka honey (Leptospermum scoparium) and honey from some other Leptospermum species the phytochemical activity can be high, with a broad spectrum of antimicrobial activity. (This activity, the Unique Manuka Factor, is rated as the UMF number on honeys on sale.) Honey with a median level of hydrogen-peroxide activity and manuka honey with a median level of phytochemical activity are equally as potent as antibacterial agents in vitro, 4 although manuka honey is about twice as effective against enterococci.5 In wound care the catalase in serum and tissues decomposes to some extent the hydrogen peroxide produced by many honeys, whereas the phytochemical component of Leptospermum honey maintains its activity. Also, the glucose oxidase which produces the hydrogen peroxide in honey only becomes active when honey is diluted, and its acidity is neutralised by exudate. In contrast, the phytochemical factor in Leptospermum honey is active in full-strength honey, giving a more potent antibacterial action that diffuses into the depth of infected tissues, making it the honey chosen for sale for wound care.
ใช้น้ำผึ้งเลือก The potency of honey's antibacterial activity can vary up to a hundred-fold.2 Honey's antibacterial activity is partly due to the high osmolarity created by its sugar content, although this reduces as it is diluted by exudate. Honey with no antibacterial activity beyond its osmolarity ceases to be effective against Staphylococcus aureus when diluted with three or four times its volume of exudate.3 However, honey produced specifically for wound care can still be inhibitory if diluted to 45-60 times its volume. Honey's antimicrobial activity is also due to: Hydrogen peroxide, which is formed in a 'slow-release' manner by the glucose oxidase added by bees during its production Phytochemicals from the nectar of particular plant species. Both activities can vary from sample to sample. In manuka honey (Leptospermum scoparium) and honey from some other Leptospermum species the phytochemical activity can be high, with a broad spectrum of antimicrobial activity. (This activity, the Unique Manuka Factor, is rated as the UMF number on honeys on sale.) Honey with a median level of hydrogen-peroxide activity and manuka honey with a median level of phytochemical activity are equally as potent as antibacterial agents in vitro, 4 although manuka honey is about twice as effective against enterococci.5 In wound care the catalase in serum and tissues decomposes to some extent the hydrogen peroxide produced by many honeys, whereas the phytochemical component of Leptospermum honey maintains its activity. Also, the glucose oxidase which produces the hydrogen peroxide in honey only becomes active when honey is diluted, and its acidity is neutralised by exudate. In contrast, the phytochemical factor in Leptospermum honey is active in full-strength honey, giving a more potent antibacterial action that diffuses into the depth of infected tissues, making it the honey chosen for sale for wound care.
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