Conclusions: Thisapproachisamodelforunderstandingtheculturalhistoryofplantsandtheirroleas
resourcesforhealthcare. “Dictamnus” showshowtransmissionoftraditionalknowledgeaboutmateria
medica,over26centuries,representsremarkablelevelsofdevelopmentandinnovation.Allthisleadusto
callattentionto D. albus and D. hispanicus whicharehighlypromisingaspotentialherbaldrugleads.The
nextstepsofresearchshouldbetosystematicallyanalysephytochemical,pharmacologicalandclinical
evidenceandtodevelopsafety,pharmacologyandtoxicologyprofilesofthetraditionalpreparations.
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