Treatment with harmine attenuates cerebral edema. The wet‑dry weight method was used to evaluate brain edema. As shown in Fig. 1, brain water content was significantly increased in the TBI group, compared with the sham group at 1, 3 and 5 days following trauma. Treatment with harmine significantly reduced the tissue water content at 1, 3 and 5 days, a compared with the TBI group.