In another in vitro assay that assessed the production of 14CO2 by 14C-glutaraldehyde-treated rat red blood
cells, uptake of radioactivity by red blood cells was approximately 20% of the dose. However, the red
blood cells did not appear to metabolize the glutaraldehyde as demonstrated by similarly low amounts of
14CO2 among intact and hemolyzed red blood cells (Ranly and Horn 1990). Similar assessment using
intact and denatured liver tissue resulted in an 18-fold higher production of 14CO2 in the intact liver tissue
compared to that of denatured liver tissue and intact and hemolyzed red blood cells.