Domestic and public computer keyboards and mice were swabbed and cultured. The swabbed areas were the keys mostly pressed like the space bar, the Enter and Backspace buttons. 100% of Internet café's computers were found to be contaminated. The present study showed that microbial contamination occur on computer surfaces located in a university setting and may reflect the multiple-user environment where the possibility of contamination by individuals who are carriers of bacteria such Staphylococcus aureus is greater and the isolation of viable microorganisms suggest that the species present are able to persist for a period of time on these surfaces. It is suggested that computer keyboards and mice in institutions may act as a vehicle for the transmission of pathogenic organisms (Anastasiades, et al., 2009). The computer s keyboard and a mouse have a very dynamic environment. Food and drinks are commonly consumed in front and on top of the keyboard. This