A randomized crossover study was performed in a 16-bed, adult critical care unit at a tertiary care
hospital. Still-sedated patients, mandating at least 3 more days of mechanical ventilation, were included. The
intervention consisted in two 1-hour daily periods of music-vs-sham-MP3 listening which were performed on
Day 1 or 3 post-inclusion, with a Day 2 wash-out. “Before-after” collection of vital signs, recording of daily
sedative drug consumption and measurement of stress and inflammatory blood markers were performed.