Chicken M cells can be visualized in Meckel’s diverticulum and CT using lectins specific for Nacetyl- d-galactosamine (SBA), α- l-fucose (AAA) and N-acetyl-d-glucosamine (WGA). Only a few studies have been carried out on the actual uptake of antigen and these were limited to the uptake of Indian ink and ferritin (Bockman and Cooper, 1973; Burns, 1982; Jeurissen et al.,1999). Although uptake of ferritin by the M cells was observed, uptake by other epithelial cells also occurred; it was concluded that the phenotypes and functions of chicken M cells and regular epithelial cells are less clear cut than their mammalian equivalents (Jeurissen et al., 1999).