I had dinner with a friend recently and she started telling me about how she felt unfulfilled at work -- she had a new boss who didn't get along with her, she felt like her responsibilities were decreasing, she didn't feel as though she were learning anything new -- all of this, and also told me that she had the opportunity to work on something completely new.
She went on to tell me that she was scared -- she wasn't sure if that were the smartest thing for her to do -- leave her team (who she loved) and work that she was good at, to do something she had no idea about. And I couldn't stop screaming, "YES! YES! YES!