In addition the theoretical potential amounts in the skin are so low that they are few dimensions below the concentrations
which caused an effect on cytokine production and release.
Even assuming that some lipid nanoparticles might arrive in the systemic blood circulation, they will be very well tolerated.
Based on their composition they are rather a kind of parenteral nutrition.
In the 1990s in vivo studies showed that intravenously injected lipid nanoparticle suspensionswere verywell tolerated (Weyhers, 1995; Weyhers et al., 1995).