Aminoguanidine interferes with the formation of proteinbound
AGEs and was found to also inhibit the formation of
AGEs that result from the reaction of glucose with phospholipid.
Aminoguanidine appeared to inhibit only partially the
formation of AGE-associated chromophores (Fig. 2A). This
may be explained by the formation of aminoguanidine AGE
addition products, which themselves absorb in the near
ultraviolet (30). Inhibition by aminoguanidine of lipid advanced
glycosylation also resulted in inhibition of lipid oxidation.
Aminoguanidine inhibited lipid oxidation in a fashion
analogous to the lipophilic antioxidant, BHT. BHT did not