Conclusions
In conclusion, the study demonstrates that mulberry extracts significantly improve deranged carbohydrate metabolism in STZ-induced diabetic rats. The mechanism of in vivo
15 journal of functional foods 8C (2014) 9–17
antidiabetic action of mulberry bioactive components most
likely involves intracellular pathways involved in insulin signaling or glucose homeostasis. The suppression of oxidative
stress may also contribute, at least in part, to the antidiabetic
action of mulberry. The results suggest that mulberry leaves
preparations can be used as a nutraceutical agent to ameliorate diabetes type 2 and might also be useful in preventing
secondary diabetic complications. The observed differences in
anti-diabetic and antioxidative properties between ethanol and
acetone extracts and both extracts and dried leaves suggest
that the effectiveness exerted by mulberry leaves preparations may depend on the extraction process