Based on the results of the possibility exists that the absorption of the pyrethroids in rat skin
was enhanced by the use of acetone as a vehicle with its increased
volume. However, this same data suggests that the absorption of the
pyrethroids in human skin would not be affected by the larger volume
of acetone. Nevertheless, it is best to minimize the volume of volatile
organic vehicles used in dermal absorption studies such that the
penetration of the test chemical is not affected by its use.