Estimated Incidence and Factors Associated with Development of BRONJ
IV bisphosphonates and incidence of BRONJ
The clinical efficacy of IV bisphosphonates for the treatment of hypercalcemia and bone
metastases is well established.
IV bisphosphonate exposure in the setting of managing
malignancy remains the major risk factor for BRONJ. Based on case series, case-controlled and
cohort studies, estimates of the cumulative incidence of BRONJ range from 0.8%-12%.