Transplantation procedure
Preparative treatment was performed according to the primary
disease and type of transplant. Generally, patients
with lymphoid malignancy were conditioned using a total
body irradiation (TBI)-containing regimen (12 Gy) that
included cyclophosphamide (CY) at 120 mg/kg with or without
cytarabine at 8 g/m2
. Conversely, patients with myeloid
malignancy were conditioned using a non-TBI-containing
regimen that included oral busulfan (BU) at 16 mg/kg or
intravenous BU at 12.8 mg/kg and CY at 120 mg/kg. Plasma
concentrations of BU were not monitored. Patients with
severe aplastic anemia were also conditioned using a total
lymphoid irradiation-containing regimen. Reducedintensity
conditioning regimens consisted of fludarabinebased
regimens with or without low-dose TBI. Cyclosporine
or tacrolimus plus short-term methotrexate were used for
prophylaxis. Tacrolimus was used in cases of unrelated or
mismatched transplantation