Conclusion
The investigated C. asiatica purified extract (Centevita™) has shown antiaging topical efficacy acting on free-radical-induced oxidative stress and cytokine-induced skin inflammaging, whereas no statistical significance was achieved in the SCB count. As per the MDA assay, although the observed reduction of the formation of MDA was quite remarkable, it has shown no statistical significance, due to the damage that occurred to one of the control samples. It would be necessary to repeat the MDA assay, if possible with a higher sample numerosity, in order to correctly define the free-radical scavenging properties of the extract.
On the other side, the extract has shown a clear prevention of the phenomenon of glycation, targeting in a pleiotropic and complementary way the biochemical and cellular bases of skin aging. Although several publications confirm the biological activity of C. asiatica compounds,14–16 the underlying mechanisms involved in the skin’s physiological effects are not yet fully understood,17,18 even if gene expression changes have been reported in human fibroblasts.17–20
The clinical evaluations have further confirmed the observed in vitro properties. Additional investigations are needed to further confirm the observed results as well as to elucidate the molecular mechanisms at the base of the biological activity.