cytotoxic activity of the extract for the HL-60 cells is due to a cumulative effect of the isolated antiproliferative substances including ursolic, 23-hydroxyursolic, oleanolic, and corosolic acids, orsellinic acid methyl ester,erythrodiol, and scopoletin.
Compounds 13 share structural similarities with the class of cannabinoids. Consequently, their interaction was investigated
with receptors that are targeted by endo-, phyto-, and synthetic cannabinoids. Neither of the compounds showed significant affinity to the major radioligand CB1, CB2, 5-HT1A, and TRPV1 receptor binding site at a concentration of 20 μM (Figure 1). However, compound 2 and the mixture of 3 indicated the tendency to interact weakly with the TRPV1 and the CB2 receptor, respectively.