Herbs are nature's gift give to mankind. Humans have known about used herbs in the treatment of this disease since Neanderthal in Iraq. The current, tomb was found to have used herbs for thousands of years ago, the Indians in Mexico used cactus (Peyate) are disinfectant and wound healing. At present, it is found that cactus has a sedative effect. About 4000 years ago, the Sumerians had colonization at the river Tigris and Euphrates, at present is Iraq used herbs such as opium, licorice, time and mustard, and later the Babylonians used more herbs from the Sumerians such as saffron, coriander seeds, cinnamon, and garlic.