There were no significant differential medication side effects or dosing patterns in mothers. The mean daily doses were 23.8 mg for escitalopram monotherapy, 244.8 mg for bupropion monotherapy, and 24.3 mg of escitalopram and 314.3 mg of bupropion for the combination treatment. There was no significant difference in the percentage of children at baseline or in the past who received psychiatric treatment by maternal treatment.There were, however, significant differences in this measure during the study,with 31.5%,20.6%,and 8.7% of children whose mothers were receiving the combination treatment,bupropion monotherapy, and escitalopram monotherapy, respectively (p,0.02),receiving psychiatric treatment.These findings suggest that the greater improvement among children whose mothers were receiving escitalopram monotherapy could not be explained by the children having received treatment; the children of mothers in the escitalopram monotherapy group received the least amount of treatment.