I've had multiple requests for some information on my build, so here you go. I'm a level 100 Tank in POE, and am built for end-game bosses (optimized for minimizing risk). I've melee facetanked all bosses (with pretty much all mods) many times -- which also means you can solo any maps/mods in the game. As you can see in the videos thread listed below, I've done many World Firsts (defined as the first recorded evidence of that fight with key mods), done some AFK boss vids (to show how tanky he can be), etc. That being said, while every boss/every mod is doable (at least I havn't found one I can't do), some are often not worth the risk: -max Crema (+ other mods obviously can make it riskier), -max Shock and Horror (ditto), -max Dominus (ditto). And of course, Uber Queen Atziri is a whole new ball game of challenge, especially for melee. However, if you just levelled (or are 100), then there is minimal risk of loss (unless you are in HC).