In contrast to the high concentrations of chemotherapeutic agents used in the above studies,COS has greater potential for clinical application because of its safety, biodegradability, and biocompatibility. Our histopathological examination and skin lesion scoring revealed no hair folliculitis, pustules, or inflammatory cell infiltration, and only occasional, inconspicuous fungal elements, in the 5% COS group, similarly to the positive control (FCZ) group.