adicals mediated lipid peroxidation of hepatocellular mem- brane (Kume et al., 2004). This pathophysiological sequence sets the scene for considering antioxidant therapy as an ad- junct in the management of diabetes. Several studies have re- cently dealt with either maintenance of antioxidant defense of diabetic liver or reduction of peroxidative stress induced he- patic damage in experimental models (Baydas et al., 2002; Cho et al., 2002; Hu ̈ nkar et al., 2002). Hence, it is recommended that a therapy with antioxidants may signify a useful pharma- cologic overture to the management of diabetes.