As with any meta-analysis, our study shares the limitations of the original studies. Methods for the diagnosis of
incident DM varied among trials, which is common in such studies. In the original West of Scotland Coronary Prevention
Study (WOSCOPS) trial, the diagnostic criteria for DM were nonstandard, with a requirement for an increase in
fasting glucose of 2.0 mmol/L during the trial. However, for the present analysis, standard criteria for the diagnosis of
DM from a reanalysis of WOSCOPS were used.11 These data were made available in the previously published metaanalysis
by Sattar et al.2