Background: The recentGlobalInitiativeforAsthmamanagement
strategy recommendsachievingsymptomcontrolandminimizingthe
future riskofpooroutcomesasprioritiesforasthmamanagement.
Objective: The objectivewastoquantifytheassociationbetween
symptom controlandhealth-relatedqualityoflifeinasthma.
Methods: In aprospectivelyrecruitedrandomsampleofadultswith
asthma, weascertainedsymptomcontrolandmeasuredhealth-
related qualityoflifeusingageneric(EuroQol five-dimensional
questionnaire[EQ-5D])andadisease-specific (AsthmaQualityofLife
Questionnaire)instrument,toestimateEQ-5Dand five-dimensional
Asthma QualityofLifeQuestionnaire(AQL-5D)utilities,respectively.
We measuredtheadjusteddifferenceinutilitiesacrosssymptom
control levelsandcalculatedthelossofpredictiveefficiency dueto
aggregating multiplesymptomsintoonesymptomcontrolvariable.
Results: The final sampleincluded958observationsfrom494indi-
viduals (meanageatbaseline52.2 14.5 years;67.0%women).
Asthma wassymptomaticallycontrolled,partiallycontrolled,and
uncontrolledin269(28.1%),367(38.3%),and322(33.6%)observations,
respectively.Apersonwithsymptomaticallyuncontrolledasthma
wouldgain0.0512(95%CI0.0339–0.0686)inEQ-5Dor0.0802(95%CI
0.0693–0.0910)inAQL-5Dutilitiesbyachievingsymptomcontrol.The
lossofpredictiveefficiencywas55.4%and27.6%forEQ-5DandAQL-5D
utilities,respectively. Conclusions: Asthmasymptomcontrolstatus
correspondswellwithbothgenericanddisease-specific quality-of-life
measures.Thetrade-off,however,betweeneaseofuseandpredictive
powershouldbereconsideredindevelopingsimplified measuresof
control.Ourresultshavedirectrelevanceininformingdecision-
analyticmodelsofasthmaanddeducingtheeffectofinterventions
on qualityoflifethroughtheirimpactonasthmacontrol.
Keywords: asthma,observationalstudies,qualityoflife,regression
analysis.
Background: The recentGlobalInitiativeforAsthmamanagementstrategy recommendsachievingsymptomcontrolandminimizingthefuture riskofpooroutcomesasprioritiesforasthmamanagement.Objective: The objectivewastoquantifytheassociationbetweensymptom controlandhealth-relatedqualityoflifeinasthma.Methods: In aprospectivelyrecruitedrandomsampleofadultswithasthma, weascertainedsymptomcontrolandmeasuredhealth-related qualityoflifeusingageneric(EuroQol five-dimensionalquestionnaire[EQ-5D])andadisease-specific (AsthmaQualityofLifeQuestionnaire)instrument,toestimateEQ-5Dand five-dimensionalAsthma QualityofLifeQuestionnaire(AQL-5D)utilities,respectively.We measuredtheadjusteddifferenceinutilitiesacrosssymptomcontrol levelsandcalculatedthelossofpredictiveefficiency duetoaggregating multiplesymptomsintoonesymptomcontrolvariable.Results: The final sampleincluded958observationsfrom494indi-viduals (meanageatbaseline52.2 14.5 years;67.0%women).Asthma wassymptomaticallycontrolled,partiallycontrolled,anduncontrolledin269(28.1%),367(38.3%),and322(33.6%)observations,respectively.Apersonwithsymptomaticallyuncontrolledasthmawouldgain0.0512(95%CI0.0339–0.0686)inEQ-5Dor0.0802(95%CI0.0693–0.0910)inAQL-5Dutilitiesbyachievingsymptomcontrol.Thelossofpredictiveefficiencywas55.4%and27.6%forEQ-5DandAQL-5Dutilities,respectively. Conclusions: Asthmasymptomcontrolstatuscorrespondswellwithbothgenericanddisease-specific quality-of-lifemeasures.Thetrade-off,however,betweeneaseofuseandpredictivepowershouldbereconsideredindevelopingsimplified measuresofcontrol.Ourresultshavedirectrelevanceininformingdecision-analyticmodelsofasthmaanddeducingtheeffectofinterventionson qualityoflifethroughtheirimpactonasthmacontrol.Keywords: asthma,observationalstudies,qualityoflife,regressionanalysis.
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