1. Introduction
2. Safety considerations of plant cell, tissue and organ culture processes
3. Basic guidelines for biosafety and toxicological evaluation of PCTOC raw material/products
4. Biosafety and toxicological evaluation of PCTOC raw material/product
4.1. General
4.2. Biosafety evaluation of TCMGARs
4.3. Efficacy of TCMGARs
5. Conclusion and outlook
Conflict of interest
Acknowledgements
References