High heelsareamajorsourceofchronicl

High heelsareamajorsourceofchroniclowerlimbpain.Yet,morethanonethirdofallwomen
compromise healthforlooksandwearhighheelsonadailybasis.Changingfrom flat footweartohigh
heels induceschronicmuscleshorteningassociatedwithdiscomfort,fatigue,reducedshockabsorption,
and increasedinjuryrisk.However,thelong-termeffectsofhigh-heeledfootwearonthemusculoske-
letal kinematicsofthelowerextremitiesremainpoorlyunderstood.Herewecreateamultiscale
computational modelforchronicmuscleadaptationtocharacterizetheacuteandchroniceffectsof
global muscleshorteningonlocalsarcomerelengths.Weperformacasestudyofahealthyfemale
subject andshowthatraisingtheheelby13cmshortensthegastrocnemiusmuscleby5%whilethe
Achilles tendonremainsvirtuallyunaffected.Ourcomputationalsimulationindicatesthatmuscle
shortening displayssignificant regionalvariationswithextremevaluesof22%inthecentralgastro-
cnemius. Ourmodelsuggeststhatthemusclegraduallyadjuststoitsnewfunctionallengthbyachronic
loss ofsarcomeresinseries.Sarcomerelossvariessignificantly acrossthemusclewithanaveragelossof
9%, virtuallynolossattheproximalanddistalends,andamaximumlossof39%inthecentralregion.
These changesrepositiontheremainingsarcomeresbackintotheiroptimaloperatingregime.
Computational modelingofchronicmuscleshorteningprovidesavaluabletooltoshapeourunder-
standing oftheunderlyingmechanismsofmuscleadaptation.Ourstudycouldopennewavenuesin

ผลลัพธ์ (ไทย) 1:

Heelsareamajorsourceofchroniclowerlimbpain สูง ยัง morethanonethirdofallwomenทำ healthforlooksandwearhighheelsonadailybasis Changingfrom แบน footweartohighส้น induceschronicmuscleshorteningassociatedwithdiscomfort ล้า reducedshockabsorptionและ increasedinjuryrisk อย่างไรก็ตาม thelong-termeffectsofhigh-heeledfootwearonthemusculoske -letal kinematicsofthelowerextremitiesremainpoorlyunderstood Herewecreateamultiscalemodelforchronicmuscleadaptationtocharacterizetheacuteandchroniceffectsof คำนวณmuscleshorteningonlocalsarcomerelengths โลก Weperformacasestudyofahealthyfemaleเรื่อง andshowthatraisingtheheelby13cmshortensthegastrocnemiusmuscleby5% whiletheอคิลลีส tendonremainsvirtuallyunaffected Ourcomputationalsimulationindicatesthatmuscleเนยขาว displayssignificant regionalvariationswithextremevaluesof22% inthecentralgastro-cnemius Ourmodelsuggeststhatthemusclegraduallyadjuststoitsnewfunctionallengthbyachronicofsarcomeresinseries ขาดทุน Sarcomerelossvariessignificantly acrossthemusclewithanaveragelossof9%, virtuallynolossattheproximalanddistalends, andamaximumlossof39% inthecentralregionChangesrepositiontheremainingsarcomeresbackintotheiroptimaloperatingregime เหล่านี้คำนวณ modelingofchronicmuscleshorteningprovidesavaluabletooltoshapeourunder-oftheunderlyingmechanismsofmuscleadaptation ยืน Ourstudycouldopennewavenuesin

ผลลัพธ์ (ไทย) 2:

heelsareamajorsourceofchroniclowerlimbpain.Yet สูง morethanonethirdofallwomen
ประนีประนอม healthforlooksandwearhighheelsonadailybasis.Changingfrom แบน footweartohigh
ส้น induceschronicmuscleshorteningassociatedwithdiscomfort อ่อนเพลีย reducedshockabsorption,
และ increasedinjuryrisk.However, thelong-termeffectsofhigh-heeledfootwearonthemusculoske-
letal kinematicsofthelowerextremitiesremainpoorlyunderstood.Herewecreateamultiscale
คำนวณ modelforchronicmuscleadaptationtocharacterizetheacuteandchroniceffectsof
ทั่วโลก muscleshorteningonlocalsarcomerelengths.Weperformacasestudyofahealthyfemale
เรื่อง andshowthatraisingtheheelby13cmshortensthegastrocnemiusmuscleby5% whilethe
จุดอ่อน tendonremainsvirtuallyunaffected.Ourcomputationalsimulationindicatesthatmuscle
สั้นลง displayssignificant regionalvariationswithextremevaluesof22% inthecentralgastro-
cnemius Ourmodelsuggeststhatthemusclegraduallyadjuststoitsnewfunctionallengthbyachronic
สูญเสีย ofsarcomeresinseries.Sarcomerelossvariessignificantly acrossthemusclewithanaveragelossof
9% virtuallynolossattheproximalanddistalends, andamaximumlossof39% inthecentralregion.
changesrepositiontheremainingsarcomeresbackintotheiroptimaloperatingregime เหล่านี้.
คำนวณ modelingofchronicmuscleshorteningprovidesavaluabletooltoshapeourunder-
ยืน oftheunderlyingmechanismsofmuscleadaptation.Ourstudycouldopennewavenuesin

ผลลัพธ์ (ไทย) 3:

heelsareamajorsourceofchroniclowerlimbpain สูง แต่ morethanonethirdofallwomen
ประนีประนอม healthforlooksandwearhighheelsonadailybasis . changingfrom ส้นแบน footweartohigh

reducedshockabsorption induceschronicmuscleshorteningassociatedwithdiscomfort , ความเมื่อยล้า , , และ increasedinjuryrisk อย่างไรก็ตาม thelong termeffectsofhigh heeledfootwearonthemusculoske -
letal kinematicsofthelowerextremitiesremainpoorlyunderstood . herewecreateamultiscale

โลกคอมพิวเตอร์ modelforchronicmuscleadaptationtocharacterizetheacuteandchroniceffectsof muscleshorteningonlocalsarcomerelengths . weperformacasestudyofahealthyfemale

เรื่อง andshowthatraisingtheheelby13cmshortensthegastrocnemiusmuscleby5 % และจุดอ่อน tendonremainsvirtuallyunaffected .ourcomputationalsimulationindicatesthatmuscle
-
% เนยขาว displayssignificant regionalvariationswithextremevaluesof22 inthecentralgastro cnemius . ofsarcomeresinseries การสูญเสีย ourmodelsuggeststhatthemusclegraduallyadjuststoitsnewfunctionallengthbyachronic

sarcomerelossvariessignificantly acrossthemusclewithanaveragelossof
9 % virtuallynolossattheproximalanddistalends , ,andamaximumlossof39 % inthecentralregion .
เหล่านี้ changesrepositiontheremainingsarcomeresbackintotheiroptimaloperatingregime .
-
modelingofchronicmuscleshorteningprovidesavaluabletooltoshapeourunder การคำนวณ ourstudycouldopennewavenuesin ยืน oftheunderlyingmechanismsofmuscleadaptation .