Results: Most patients (93%) were male; they had a mean (SD) age of 68 (9) years and mild to very severe COPD
(post-bronchodilator FEV1 52 (16)% predicted). Multivariate analyses showed that anxiety, depression, or both
conditions were associated with poor HRQoL (for all SGRQ domains). The association between anxiety and total
HRQoL score was 6.7 points higher (indicating a worse HRQoL) in current workers than in retired individuals.
Estimates for patients with “both anxiety and depression” were 5.8 points lower in stage I-II than in stage III-IV
COPD, and 10.2 points higher in patients with other comorbidities than in those with only COPD.