specifically, 300 mg three
times daily.8 Finally, the proportions of patients
who had an S. aureus isolate that was resistant to
clindamycin or TMP-SMX (5.2% and 0.2%, respectively)
were relatively low. Given the low prevalence
of resistance, its contribution to treatment
failure is unclear, although there was a trend
toward a lower clindamycin cure rate for infections
caused by clindamycin-resistant S. aureus versus
clindamycin-susceptible isolates (73.3% vs.
91.7%, P = 0.06), which also raises important questions
about the spontaneous response rate.