Seventy male Sprague-Dawley rats, aged six weeks and weighing 196.09 ± 10.46 g, were randomly divided into two groups: the first group of 20 rats was fed with a basal diet and another group of 50 rats were fed with a high fat (HF) diet. After two weeks, rats fed the HF-diet were induced to hyperglycemia by two doses of STZ injections (20 and 30 mg/kg; i.p.)