Wound healing involves a chain of well orchestrated, biochemical
and cellular events, leading to the growth and regeneration of
wounded tissue. In coetaneous wound healing, the inflammation
stage begins immediately after injury, first with vasoconstriction
that favours homeostasis and releases inflammation mediators. The
proliferative phase is characterized by granulation tissue proliferation
formed mainly by fibroblast and the angiogenesis process. The
remodelling stage is characterized by reformulations and improvement
in the components of the collagen fibers that increases the
tensile strength. Although the rate of collagen synthesis slow down
after about three weeks, collagen cross-linking and reorganisation
occur for months after injury in the remodelling phase of repair