The findings from this study suggested that the Triphala formulation
and its individual constituents have an inhibitory effect
on metabolism enzymes when consumed along with therapeutic
products. Further the inhibitory effects were relatively comparable
to all the constituents tested, despite the variability of the content
of biomarker. Triphala formulation and its ingredients are likely to
inhibit drug metabolizing enzymes, but less likely to produce significant
drug interactions. Certain major factors of metabolism such
as competition between co-administered drugs, unspecific interactions
with proteins, and enzyme induction due to chronic intake
are not addressed in this in vitro assay. However, data presented in
this study clearly suggested that herbal products containing gallic
acid may have the potential to inhibit the metabolism of certain
co-administered drugs.