In conclusion, in this study we showed encouraging results on tomato defense against early blight disease using isolated PGPRs. TN Vel-35 is a promising PGPR for preventing early blight disease, thereby improving tomato fruit weight. Our finding also provides evidence that the induced defense responses of PGPRtreated tomato plants to A. solani are associated with enhanced POX and PPO biosyntheses. The POX and PPO genes are promising candidates that could be used in development of disease-resistant transgenic varieties by genetic engineering.