The extent of MA-related impairment/damage, and whether it is permanent or reversible
over time has not yet been determined. A study by McCann et al7 indicates lasting effects of
neurocognitive memory deficits were observed in a cohort of abstinent MA users. Similarly,studies found deficits among both abstinent and non-abstinent MA users in verbal memory,
perceptual motor speed and tasks that require mental flexibility.8,9 However, Chang et al.10
found cognitive performance of MA dependent adults who were abstinent for two or more
weeks was in the normal range on standard neuropsychological tests; however, they were
slower on several tasks that required working memory. Some research indicates acute doses
of MA administered to drug-naïve subjects produced improvements in cognitive processing,
while other studies found no cognitive improvements associated with amphetamine
administration.1, 6 Scott et al.11 concluded that the acute cognitive effects of therapeutic
doses of MA tend to increase attentiveness and speed of processing, but also decrease ability
to filter information.
The extent of MA-related impairment/damage, and whether it is permanent or reversibleover time has not yet been determined. A study by McCann et al7 indicates lasting effects ofneurocognitive memory deficits were observed in a cohort of abstinent MA users. Similarly,studies found deficits among both abstinent and non-abstinent MA users in verbal memory,perceptual motor speed and tasks that require mental flexibility.8,9 However, Chang et al.10found cognitive performance of MA dependent adults who were abstinent for two or moreweeks was in the normal range on standard neuropsychological tests; however, they wereslower on several tasks that required working memory. Some research indicates acute dosesof MA administered to drug-naïve subjects produced improvements in cognitive processing,while other studies found no cognitive improvements associated with amphetamineadministration.1, 6 Scott et al.11 concluded that the acute cognitive effects of therapeuticdoses of MA tend to increase attentiveness and speed of processing, but also decrease abilityto filter information.
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