Consequences of antibiotic treatment during
pregnancy
After the publication (2008) of the 7-year follow-up
of the ORCALE II trial, which showed an increased
risk of cerebral palsy in neonates whose mothers
received antibiotics during pregnancy, more studies
focused on possible adverse effects of maternal antibiotic
use during pregnancy [38].
Wright et al. [39&&] found that early-onset sepsis
caused by antibiotic-resistant microorganisms in
neonates was associated with maternal antibiotic
use during pregnancy and delivery, including antibiotics
for bacteriuria (6% of prescriptions). Main
indications for antibiotic prescriptions were preterm
PROM and chorioamnionitis