Boonpucknavig S, et al. studies in hamster of OV infection
After 8 weeks, hamsters develop a “mesangioproliferative glomerulonephritis”, characterized by deposition of immune complexs(ICs), complement component 3, and OV tegumental antigen
After 12 weeks, show a complete obsolesce of the glomeruli characterized by deposition of Amyloid(AA protein), Tubular atrophy, interstitial inflammation, and tubular fibrosis