Kovacs et al.9-11 evaluated an initial warfarin dose of 10
mg in a series of studies. The first of these studies randomized
111 hospitalized patients with confirmed venous
thromboembolism to warfarin initiation using either a 10-
mg nomogram or physician-determined dosing (standard
care).9 Unlike the warfarin dosing nomograms described previously,
7,8 the one derived by Kovacs et al. recommends specific
warfarin doses rather than a range (Table 2), improving
the ease of use and providing greater standardization in dosing
strategy. The Kovacs nomogram is also more aggressive,
recommending higher warfarin doses for a given INR level
compared with the Crowther nomogram (Table 130).