The lack of fit for the Fick model and the good fit of the Fito and Chiralt model and the Barbosa Júnior et al. model provides insight into the applicability of each model for the studied process. The first model calculates the effective diffusivity as a mean for the entire duration of the osmotic process and disregards the hydrodynamic process during PVOD, reducing the quality of the model to fit this process. Fito and Chiralt's model considers the diffusion and hydrodynamic mechanisms during PVOD, achieving a better fit to the data. Barbosa Júnior et al. model considers the Deff variation during the osmotic process, and it calculates one effective diffusion value for each time point, improving the overall estimates of the response and, accordingly, the adjustment of the model.