The purpose of this study was to investigate dermal
pharmacokinetics of terpinen-4-ol in rats following
topical administration of plai oil derived
from the rhizomes of Zingiber cassumunar Roxb.
Unbound terpinen-4-ol concentrations in dermal
tissue were measured by microdialysis. The dermal
pharmacokinetic study of terpinen-4-ol was
performed under non-occlusive conditions. The
oil was topically applied at a dose of 2, 4, and
8mg/cm2 plai oil corresponding to the amount of
1.0, 1.9, and 3.8 mg/cm2 terpinen-4-ol, respectively.
Following topical application of the oil, terpinen-
4-ol rapidly distributed into the dermis
The purpose of this study was to investigate dermalpharmacokinetics of terpinen-4-ol in rats followingtopical administration of plai oil derivedfrom the rhizomes of Zingiber cassumunar Roxb.Unbound terpinen-4-ol concentrations in dermaltissue were measured by microdialysis. The dermalpharmacokinetic study of terpinen-4-ol wasperformed under non-occlusive conditions. Theoil was topically applied at a dose of 2, 4, and8mg/cm2 plai oil corresponding to the amount of1.0, 1.9, and 3.8 mg/cm2 terpinen-4-ol, respectively.Following topical application of the oil, terpinen-4-ol rapidly distributed into the dermis
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