reflect age-related immunologic changes similar to those proposed
for humans. The canine immune system undergoes a
process of age-related compromise in function, with declines
in leukocyte proliferation, mitogen stimulation, chemotaxis,
phagocytosis, and various other immunologic parameters.36–38
These age-associated changes in immunity are similar between
dogs and humans.39,40 Age-related changes of polymorphonuclear
cell function impair P. aeruginosa phagocytosis, delay
corneal clearance, and increase corneal bacterial loads.